"DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology" has been acclaimed by the worldwide medical community as the standard-setting oncology reference. Its primary goal is to present the practicing oncologist with the practical as well as cutting-edge information needed to ensure the best possible care for each individual patient. The hallmark of this book from its inception and a major reason it has gained worldwide acceptance as the definitive source of cancer information has been its approach to the treatment of cancer patients by stage of presentation with a tightly coordinated description of the role of each treatment modality in the care of individual patients. To ensure a balance multidisciplinary approach, a surgeon, a medical oncologist, and a radiation oncologist author each of the major treatment chapters. Each of the major treatment sections is preceded by an updated, brief chapter describing the molecular biology of that cancer and the prospects this new information holds for the improved management of cancer patients. Greater emphasis has been given in recent editions to the increasing importance of molecular biology and cancer screening and prevention, as well as palliative care, supportive oncology and quality of life issues. This brand-new edition includes instant access to the fully searchable, updated text! Plus, the smart search integrates results from...cancer-related medication monographs; NCCN guidelines; patient education handouts; an image bank with hundreds of additional images; linked references to Pub Med articles; and, quarterly updates.

Part I: Molecular Biology of Cancer 1. The Cancer Genome NEW! 2. Mechanisms of Genomic Instability 3. Epigenetics of Cancer NEW! 4. Telomeres, Telomerase, and Cancer 5. Cell Signaling, Growth Factors and their Receptors 6. Cell Cycle 7. Mechanisms of Cell Death 8. Cancer Metabolism NEW! 9. Angiogenesis 10. Invasion and Metastasis 11. Cancer Stem Cells 12. Biology of Personalized Cancer Medicine NEW! Part II: Etiology and Epidemiology of Cancer Section 1: Etiology of Cancer 13. Tobacco 14. Cancer Susceptibility Syndromes 15. DNA Viruses 16. RNA Viruses 17. Inflammation 18. Chemical Factors 19. Physical Factors 20. Dietary Factors 21. Obesity and Physical Activity Section 2: Epidemiology of Cancer 22. Epidemiologic Methods 23. Global Cancer Incidence and Mortality 24. Changes in Cancer Mortality Part III: Principles of Cancer Treatment 25. Surgical Oncology: General Issues 26. Surgical Oncology: Laparoscopic Surgery 27. Radiation Oncology 28. Medical Oncology 29. Assessment of Clinical Response NEW! 30. Cancer Immunotherapy 31. Health Services Research and Economics of Cancer Care Part IV: Pharmacology of Cancer Therapeutics Section 1: Chemotherapy Agents 32. Pharmocokinetics and Pharmacodynamics 33. Pharmacogenomics 34. Alkylating Agents 35. Platinum Analogs 36. Antimetabolites 37. Topoisomerase Interactive Agents 38. Antimicrotubule Agents 39. Targeted Therapy with Small Molecule Kinase Inhibitors NEW! 40. Histone Deacetylase Inhibitors and Demethylating Agents 41. Proteosome Inhibitors 42. Poly (ADP-ribose) Polymerase Inhibitors NEW! 43. Miscellaneous Chemotherapeutic Agents Section 2: Biotherapeutics 44. Interferons 45. Interleukin Therapy 46. Antisense Agents 47. Antiangiogenesis Agents 48. Monoclonal Antibodies 49. Endocrine Manipulation Part V: Cancer Prevention 50. Preventive Cancer Vaccines 51. Tobacco Dependence and Its Treatment 52. Role of Surgery in Cancer Prevention 53. Principles of Cancer Chemoprevention 54. Retinoids, Carotinoids, and other Micronutrients 55. Drugs Used in Chemoprevention Part VI: Cancer Screening 56. Principles of Cancer Screening 57. Early Detection Using Proteomics NEW! 58. Screening for Gastrointestinal Cancers 59. Screening for Gynecologic Cancers 60. Screening for Breast Cancer 61. Screening for Prostate Cancer NEW! 62. Screening for Lung Cancer 63. Genetic Counseling Part VII: Specialized Techniques in Cancer Management 64. Vascular Access and Specialized Technique in Drug Delivery 65. Interventional Radiology 66. Functional Imaging 67. Molecular Imaging 68. Photodynamic Therapy 69. Biomarkers Part VIII: Practice of Oncology 70. Design and Analysis of Clinical Trials Section 1. Cancer of the Head and Neck 71. Molecular Biology of Head and Neck Cancers 72. Treatment of Head and Neck Cancer 73. Rehabilitation after Treatment of Head and Neck Section 2. Cancer of the Thoracic Cavity 74. Molecular Biology of Lung Cancer 75. Non-small Cell Lung Cancer 76. Small Cell and Neuroendocrine Tumors of the Lung 77. Neoplasms of the Mediastinum Section 3: Cancers of the Gastrointestinal Tract 78. Molecular Biology of the Esophagus and Stomach 79. Cancer of the Esophagus 80. Cancer of the Stomach 81. Molecular Biology of Pancreas Cancer 82. Cancer of the Pancreas 83. Molecular Biology of Liver Cancer 84. Cancer of the Liver 85. Cancer of the Biliary Tree 86. Cancer of the Small Intestine 87. Gastrointestinal Stromal Tumors 88. Molecular Biology of Colorectal Cancer 89. Cancer of the Colon 90. Cancer of the Rectum 91. Cancer of the Anal Region Section 4. Cancers of the Genitourinary System 92. Molecular Biology of Kidney Cancer 93. Cancer of the Kidney 94. Molecular Biology of the Bladder 95. Cancer of the Bladder, Ureter and Renal Pelvis 96. Molecular Biology of Prostate Cancer 97. Cancer of the Prostate 98. Cancer of the Urethra and Penis 99. Cancer of the Testis Section 5. Gynecologic Cancers 100. Molecular Biology of Gynecologic Cancers 101. Cancer of the Cervix, Vagina and Vulva 102. Cancer of the Uterine Body 103. Gestational Trophoblastic Diseases 104. Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma Section 6. Cancer of the Breast 105. Molecular Biology of Breast Cancer 106. Malignant Tumors of the Breast Section 7. Cancer of the Endocrine System 107. Molecular Biology of Endocrine Tumors 108. Thyroid Tumors 109. Parathyroid Tumors 110. Adrenal Tumors 111. Pancreatic Endocrine Tumors 112. Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome 113. Multiple Endocrine Neoplasias Section 8. Sarcomas of Soft Tissue and Bone 114. Molecular Biology of Sarcomas NEW! 115. Soft Tissue Sarcoma 116. Sarcomas of Bone Section 9. Cancers of the Skin 117. Cancer of the Skin 118. Molecular Biology of Cutaneous Melanoma 119. Cutaneous Melanoma Section 10. Neoplasms of the Central Nervous System 120. Molecular Biology of Central Nervous System Tumors 121. Neoplasms of the Central Nervous System Section 11. Cancers of Childhood 122. Molecular Biology of Childhood Cancers 123. Solid Tumors of Childhood 124. Leukemias and Lymphomas of Childhood Section 12. Lymphomas in Adults 125. Molecular Biology of Lymphomas NEW! 126. Hodgkin""s Lymphoma 127. Non-Hodgkin""s Lymphomas 128. Cutaneous Lymphomas 129. Primary Central Nervous System Lymphoma Section 13. Leukemias and Plasma Cell Tumors 130. Molecular Biology of Acute Leukemias 131. Management of Acute Leukemias 132. Molecular Biology of Chronic Leukemias 133. Chronic Myelogenous Leukemia 134. Chronic Lymphocytic Leukemias 135. Myelodysplastic Syndromes 136. Plasma Cell Neoplasms Section 14. Other Cancers 137. Cancer of Unknown Primary Site 138. Benign and Malignant Mesothelioma 139. Peritoneal Surface Malignancy 140. Intraocular Melanoma Section 15. Immunosuppression Related Malignancies 141. AIDS-Related Malignances 142. Transplantation-Related Malignancies Section 16. Oncologic Emergencies 143. Superior Vena Cava Syndrome 144. Increased Intracranial Pressure 145. Spinal Cord Compression 146. Metabolic Emergencies Section 17. Treatment of Metastatic Cancer 147. Metastatic Cancer to the Brain 148. Metastatic Cancer to the Lung 149. Metastatic Cancer to the Liver 150. Metastatic Cancer to the Bone 151. Malignant Pleural and Pericardial Effusions 152. Malignant Ascites 153. Paraneoplastic Syndromes Section 18. Stem Cell Transplantation 154. Autologous Stem Cell Transplantation 155. Allogeneic Stem Cell Transplantation Section 19. Management of Adverse Effects of Treatment 156. Infections in the Cancer Patient 157. Leukopenia and Thrombocytopenia 158. Cancer Associated Thrombosis 159. Nausea and Vomiting 160. Diarrhea and Constipation 161. Oral Complications 162. Pulmonary Toxicity 163. Cardiac Toxicity 164. Hair Loss 165. Gonadal Dysfunction 166. Fatigue 167. Second Cancers 168. Neurocognitive Effects 169. Cancer Survivorship Section 20. Supportive Care and Quality of Life 170. Management of Cancer Pain 171. Nutritional Support 172. Sexual Problems 173. Psychological Issues 174. Communicating News to the Cancer Patient 175. Specialized Care of the Terminally Ill 176. Community Resources 177. Rehabilitation of the Cancer Patient Section 21. Societal Issues in Oncology 178. Regulatory Issues 179. Health Disparities in Cancer 180. Cancer on the Internet Section 22. Complementary, Alternative,and Integrative Therapies 181. Complementary, Alternative, and Integrative